Dextran Sulphate inhibits Cell Adhesion in Tissue Culture
نویسندگان
چکیده
منابع مشابه
Chondroitin sulphate inhibits connective tissue mast cells.
1. Mast cells derive from the bone marrow and are responsible for the development of allergic and possibly inflammatory reactions. Mast cells are stimulated by immunoglobulin E (IgE) and specific antigen, but also by a number of neuropeptides such as neurotensin (NT), somatostatin or substance P (SP), to secrete numerous pro-inflammatory molecules that include histamine, cytokines and proteolyt...
متن کاملDextran sulphate induced arthritis in rabbits.
Persistent effects of a short course of intra-articular dextran sulphate, dextrans, or chondroitin sulphate were examined in rabbit knees. Only dextran sulphate produced gross arthritis, associated with high synovial acid phosphatase and beta-glucuronidase activities. Synovial degradative capacity in synovium-cartilage cocultures was increased 2-fold by dextran sulphate and 1.5-fold by chondroi...
متن کاملDextran sulphate--a synthetic analogue of heparin.
The structure of the natural anticoagulant, heparin, is gradually being elucidated. As each step forward is made, attempts to synthesize molecules with the biological activity of heparin receive renewed impetus. It is now known (Jorpes, 1939) that heparin is composed of glucuronic acid and glucosamine though the mode of linkage of these two parts is not yet clear. Some of the hydroxyl groups of...
متن کاملDesulphation of dextran sulphate during kidney ultrafiltration.
The renal clearance of [3H]dextran sulphate by the isolated perfused rat kidney was associated with desulphation of the molecule, as demonstrated by ion-exchange and affinity chromatography of material resident in both glomeruli and urine samples. This process also occurred in vivo. The molecular size distribution of glomerular dextran sulphate in the perfused kidney was indistinguishable from ...
متن کاملCell adhesion century: culture breakthrough.
This theme issue, based on a Royal Society Discussion Meeting held in April 2014, is a celebration, a reflection and a prediction. To start, we celebrate the memory of Ross Granville Harrison FRS who first showed a century ago that chicken embryo nerve cells could be grown outside the animal [1]. This was the invention needed to begin the animal cell culture industry. Adhesion to a substrate wa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature New Biology
سال: 1973
ISSN: 0090-0028,2058-1092
DOI: 10.1038/newbio246174a0